Course summary

Our PhD/MPhil Stem Cell Research programme enables you to undertake a research project that will improve understanding of Stem Cell Research. Stem cells falls within our vibrant Manchester Regenerative Medicine Network (MaRMN ) comprising academics and clinicians across the University and adjacent hospitals dedicated to carrying out world class research focussed on regeneration and repair of tissues, and developing new therapeutics. Stem cells biology is an important part of this research area. The MarMN is working to facilitate research in regenerative medicine and stem cell biology from bench to bedside Those working in the area of tissue regeneration, combining tissue engineering and regenerative medicine, are developing living cell-based biological approaches to aid the repair and regeneration of damaged and diseased tissues. This is a strongly interdisciplinary field of research that combines the skills of cell, molecular and matrix biologists with expertise in other areas including that from material, engineering and physical scientists at the University and with clinical and surgical specialists in the NHS. MarMN scientists are investigating basic cellular mechanisms that regulate cell fate and devising therapeutic protocols to exploit cells for replacing injured or defective tissues (pre-clinical and clinical trials are underway). MarMN draws on major interdisciplinary strengths in stem and progenitor cell research together with gene therapy. Network members have expertise in the isolation and differentiation of stem and progenitor cells from adults and preimplantation human embryos, as well as in reprogramming of somatic cells to more naïve fates, including induced pluripotent stem cells both in vitro and in vivo. Interdisciplinary collaborative research includes the use of novel tracking strategies, 3D printing and novel materials, and biophysical approaches. Research in stem and progenitor cell biology is being applied to a number of major clinical targets, including neurodegenerative diseases, disorders of soft and hard connective tissues, diabetes and chronic tissue injury and repair. Disease modelling in vitro, including gene editing, is an increasing area of strength. We also have innovative programmes that are investigating the relationship between stem cells and cancer.