Course summary

The information provided on this page was correct at the time of publication (November 2023). For complete and up-to-date information about this course, please visit the relevant University of Oxford course page via www.graduate.ox.ac.uk/ucas. This four-year DPhil programme aims to train and nurture future leaders in the application of genomics to advance human health. It will equip them with skill sets spanning experimental and analytical genomic science in order to realise the potential of genomics and practice the qualities of fair and inspiring leadership that we will instil during the course. The first year includes taught modules focused within the first term. First-year students then undertake short research projects in up to three laboratories in three-month rotations, with further training and teaching sessions tailored to the needs of individual students. The research projects and lab visits help inform the choice of DPhil project to be undertaken over the subsequent three years of the programme. The final three years of the course will comprise doctoral research under the supervision of two named supervisors and a doctoral committee. Applicants are advised to visit the Doctoral Training Centre course webpage for further information about supervisors connected to this programme. The programme actively seeks to recruit students from very diverse backgrounds, united by a track record of academic excellence and enthusiasm for this field. Students receive world-class training, supervision, mentorship and pastoral support. Promoting excellence in research culture underlies all aspects of the programme with a commitment to support creativity, prioritise diversity and inclusion, and promote best practice. Module information The programme is focused on the following themes:

• genomic and -omic technologies (including method development, single cell genomics, imaging, model systems, CRISPR screens, genome engineering, proteomics, metabolomics, high throughput screening)

• functional genomics (gene regulation and epigenetics)

• genome biology (genetic variation, recombination, human history, evolution, palaeogenomics, pathogen genomes)

• genomics of disease (Mendelian, multifactorial traits, cancer)

• genomic analysis (bioinformatics and statistical genetics)

• from genes to clinical proof of concept (integrated drug development pipeline spanning genetic-led target discovery, structural biology, medicinal chemistry)

• application of genomics in the clinic (rare disease diagnostics, cancer therapeutics, personalised medicine and genome therapies).